The postholder will provide expert autonomous clinical practice for highly complex cardiomyopathy patients requiring initiation, optimisation, monitoring, and long-term management of Mavacamten therapy. They will assist in the introduction of other cardiac myosin inhibitors as they become available. They will act as the professional and operational lead for the service, working collaboratively across cardiology, pharmacy, imaging, genetics, and commissioning teams to ensure compliance with NICE guidance, Trust governance standards, and national service specifications. The 8a Lead Nurse/Advanced Clinical Practitioner (ACP) for inherited cardiac conditions will provide strategic, clinical, and operational leadership for the OUH Mavacamten service within the regional Inherited Cardiac Conditions (ICC) programme. The postholder will lead the implementation and delivery of the NICE TA913-approved Mavacamten pathway for patients with obstructive hypertrophic cardiomyopathy (oHCM), ensuring safe, effective, evidence-based, and equitable access to treatment across the Buckinghamshire, Oxfordshire and Berkshire West (BOB) region and wider referral network. The 8a with act as a senior clinical expert resource for inherited cardiac conditions (ICC) services, in particular for the Band 7 nurses within the ICC team
- Providing expert clinical leadership for the Mavacamten service and associated oHCM pathways.
- Delivering advanced autonomous assessment, prescribing, treatment initiation, optimisation, and monitoring of patients receiving Mavacamten. They will run clinics independently.
- Leading implementation of NICE TA913 within OUH and across the regional referral network.
- Coordinating multidisciplinary care across tertiary and local services.
- Developing sustainable operational pathways to support phased expansion of patient access.
- Ensuring robust governance, safety monitoring, audit, and outcome reporting, as well as leading Quality Improvement projects.
- Leading education and training for multidisciplinary staff across the regional network.
- Supporting research, innovation, and service development within cardiomyopathy care.
Oxford University Hospitals NHS Foundation Trust is one of the largest NHS teaching trusts in the country. It provides a wide range of general and specialist clinical services and is a base for medical education, training and research. The Trust comprises four hospitals – the John Radcliffe Hospital, Churchill Hospital and Nuffield Orthopaedic Centre in Headington and the Horton General Hospital in Banbury.
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